Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMW4GM2)

Drug Name

AZD5153 Drug Info

Synonyms

RSMYFSPOTCDHHJ-GOSISDBHSA-N; AZD-5153; 1869912-39-9; UNII-C7C7U6YEAO; C7C7U6YEAO; SCHEMBL17477306; MolPort-044-561-768; AZD 5153 [WHO-DD]; AZD 5153; EX-A1317; BCP20057; ZINC575441177; AKOS030627661; SB18713; AS-35242; J3.544.368A; (3r)-4-[2-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one; XNH; 2-Piperazinone, 4-(2-(4-(1-(3-methoxy-1,2,4-triazolo(4,3-b)pyridazin-6-yl)-4-piperidinyl)phenoxy)ethyl)-1,3-dimethyl-, (3R)-; (R)-4-(2-(4-(1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)pipe

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

Cross-matching ID

PubChem CID: 118693659
CAS Number: CAS 1869912-39-9
TTD Drug ID: DMW4GM2

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Bromodomain-containing protein 4 (BRD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CPI-0610	DMPXOYJ	Myelofibrosis	2A20.2	Phase 3	[2]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
PLX2853	DMX168L	Acute myeloid leukaemia	2A60	Phase 1/2	[1]
RVX-208	DM1LO8K	Alzheimer disease	8A20	Phase 1/2	[2]
INCB57643	DMBGU7V	Advanced malignancy	2A00-2F9Z	Phase 1/2	[1]
ABBV-744	DMTEA9C	Acute myeloid leukaemia	2A60	Phase 1	[1]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[3]
GSK525762	DMPAWBN	Haematological malignancy	2B33.Y	Phase 1	[2]
TEN010	DM4UOY5	Advanced solid tumour	2A00-2F9Z	Phase 1	[2]
PMID26924192-Compound-104	DM346EU	N. A.	N. A.	Patented	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bromodomain-containing protein 4 (BRD4)	TTRA6BO	BRD4_HUMAN	Inhibitor	[1]

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Targeting bromodomains: epigenetic readers of lysine acetylation.Nat Rev Drug Discov.2014 May;13(5):337-56.
3	Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73.
4	BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22.