General Information of Drug (ID: DMW73A8)

Drug Name
AA-123 Drug Info
Synonyms BMP agonist (prostate cancer), Thrasos Therapeutics
Indication
Disease Entry ICD 11 Status REF
Prostate cancer 2C82.0 Investigative [1]
Cross-matching ID
TTD Drug ID
DMW73A8

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID23639540C13d DMSTQGH Discovery agent N.A. Investigative [2]
PMID23639540C13a DMLXOAQ Discovery agent N.A. Investigative [2]
PMID23639540C13r DMHBZ0N Discovery agent N.A. Investigative [2]
LDN-214117 DM57Z8J Discovery agent N.A. Investigative [3]
ML347 DMR8N36 Discovery agent N.A. Investigative [2]
AA-184 DMCN4ZD Kidney injury NB92.0 Investigative [1]
AA-204 DMBGTX9 Kidney disease GC2Z Investigative [1]
AA-166 DM2BMAZ Articular cartilage disorder FA34.Y Investigative [1]
⏷ Show the Full List of 8 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bone morphogenetic protein receptor (BMPR2) TTGKF90 BMPR2_HUMAN Agonist [1]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1794).
2 Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52.
3 Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants. J Med Chem. 2014 Oct 9;57(19):7900-15.