Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMW7TZV)

Drug Name

Lenacapavir Drug Info

Synonyms

GS-6207; 2189684-45-3; N-[(1R)-1-[3-[4-Chloro-3-(cyclopropylsulfonylamino)-1-(2,2-difluoroethyl)indazol-7-yl]-6-(3-methyl-3-methylsulfonylbut-1-ynyl)pyridin-2-yl]-2-(3,5-difluorophenyl)ethyl]-2-[(2R,4S)-9-(difluoromethyl)-5,5-difluoro-7,8-diazatricyclo[4.3.0.02,4]nona-1(6),8-dien-7-yl]acetamide

Indication

Disease Entry	ICD 11	Status	REF
Human immunodeficiency virus-1 infection	1C62	Approved	[1]
Human immunodeficiency virus infection	1C62	Phase 2/3	[2]

Cross-matching ID

PubChem CID: 138059678
TTD Drug ID: DMW7TZV

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Human immunodeficiency virus Capsid p24 (HIV p24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
F4co vaccine	DM6UQNW	Human immunodeficiency virus infection	1C62	Phase 2	[4]
Vacc-4x	DMDAKZW	Human immunodeficiency virus-1 infection	1C62	Phase 2	[5]
VH4004280	DMM5L3S	Human immunodeficiency virus infection	1C62	Phase 1	[6]
VH4011499	DM1GSSM	Human immunodeficiency virus infection	1C62	Phase 1	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Human immunodeficiency virus Capsid p24 (HIV p24)	TTTWS2G	POL_HV1B1	Inhibitor	[3]

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References

1	FDA Approved Drug Products from FDA Official Website. 2022. Application Number: 215973.
2	ClinicalTrials.gov (NCT04150068) Study to Evaluate the Safety and Efficacy of Lenacapavir in Combination With an Optimized Background Regimen in Heavily Treatment Experienced Participants Living With HIV-1 Infection With Multidrug Resistance (CAPELLA). U.S. National Institutes of Health.
3	Clinical pipeline report, company report or official report of Gilead Sciences.
4	EP patent application no. 2621528, Vaccine.
5	Clinical pipeline report, company report or official report of Bionor Pharma.
6	Clinical pipeline report, company report or official report of ViiV Healthcare