General Information of Drug (ID: DMWGV8N)

Drug Name
PMID28870136-Compound-43 Drug Info
Cross-matching ID
PubChem CID
3182
ChEBI ID
CHEBI:4728
CAS Number
CAS 479-18-5
TTD Drug ID
DMWGV8N

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Drug(s) Targeting Ecto-5'-nucleotidase (CD73)
Drug Name Drug ID Indication ICD 11 Highest Status REF
TJ004309 DMFB54Y Ovarian cancer 2C73 Phase 2 [2]
GS-1423 DMS25DL Solid tumour/cancer 2A00-2F9Z Phase 1 [3]
Oleclumab DMLVNWO Solid tumour/cancer 2A00-2F9Z Phase 1 [4]
AB680 DMGONUE Pancreatic cancer 2C10 Phase 1 [5]
TJ4309 DMM3U2Q Solid tumour/cancer 2A00-2F9Z Phase 1 [6]
CPI-006 DMJSFTX Advanced cancer 2A00-2F9Z Phase 1 [7]
LY3475070 DMZLIWX Solid tumour/cancer 2A00-2F9Z Phase 1 [8]
NZV930 DMWN2FP Solid tumour/cancer 2A00-2F9Z Phase 1 [9]
PMID28870136-Compound-57 DME3HLC N. A. N. A. Patented [1]
PMID28870136-Compound-46 DM4FD7C N. A. N. A. Patented [1]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Ecto-5'-nucleotidase (CD73) TTK0O6Y 5NTD_HUMAN Inhibitor [1]

References

1 Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304.
2 ClinicalTrials.gov (NCT05001347) A Phase 2 Clinical Study of TJ004309 in Combination With Atezolizumab (TECENTRIQ?) in Patients With Advanced or Metastatic Ovarian Cancers and Selected Advanced Solid Tumors. U.S.National Institutes of Health.
3 Clinical pipeline report, company report or official report of Agenus.
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 Discovery of AB680: A Potent and Selective Inhibitor of CD73. J Med Chem. 2020 Oct 22;63(20):11448-11468.
6 ClinicalTrials.gov (NCT04322006) A Phase I/II Study of TJ004309 for Advanced Solid Tumor. U.S. National Institutes of Health.
7 Clinical pipeline report, company report or official report of Corvus Pharmaceuticals.
8 CD73's Potential as an Immunotherapy Target in Gastrointestinal Cancers. Front Immunol. 2020 Apr 15;11:508.
9 Clinical pipeline report, company report or official report of Surface oncology.