Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWIHRX)

Drug Name

inhibitor 19 Drug Info

Synonyms

CHEMBL1782887; GTPL8621; BDBM50346448; inhibitor 19 [PMID: 21476495]; 2-[2-[[[(2S,6S,9E,13S)-13-amino-2-[(4-hydroxyphenyl)methyl]-4,14-dioxo-1,5-diazacyclotetradec-9-ene-6-carbonyl]amino]methyl]phenyl]acetic acid; 2-(2-(((2S,6S,13S,E)-13-Amino-2-(4-hydroxybenzyl)-4,14-dioxo-1,5-diazacyclotetradec-9-ene-6-carboxamido)methyl)phenyl)acetic Acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 53259050
TTD Drug ID: DMWIHRX

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Leucyl-cysteinyl aminopeptidase (LNPEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US10059720, Example 80	DMBD95S	N. A.	N. A.	Patented	[3]
US10059720, Example 82	DMJ6GU9	N. A.	N. A.	Patented	[3]
US10059720, Example 84	DMKLVE4	N. A.	N. A.	Patented	[3]
US10023583, Example 5	DMZR10T	N. A.	N. A.	Patented	[4]
US10023583, Example 24	DM5LK6O	N. A.	N. A.	Patented	[4]
US10023583, Example 13	DMU21PD	N. A.	N. A.	Patented	[4]
US10023583, Example 8	DM40KU8	N. A.	N. A.	Patented	[4]
PMID23916253C17	DM35FH8	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Leucyl-cysteinyl aminopeptidase (LNPEP)	TTY2KP7	LCAP_HUMAN	Inhibitor	[2]

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References

1	The angiotensin AT4 receptor subtype as a target for the treatment of memory dysfunction associated with Alzheimer's disease. J Renin Angiotensin Aldosterone Syst. 2008 Dec;9(4):226-37.
2	Potent macrocyclic inhibitors of insulin-regulated aminopeptidase (IRAP) by olefin ring-closing metathesis. J Med Chem. 2011 Jun 9;54(11):3779-92.
3	Pyridine derivative. US10059720.
4	Bicyclic pyridine compound. US10023583.
5	Novel selective inhibitors of aminopeptidases that generate antigenic peptides. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4832-6.