Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWMFTJ)

Drug Name

2-(3-BENZOYLPHENOXY)ETHYL(HYDROXY)FORMAMIDE Drug Info

Synonyms

SB-543668; 2-(3-BENZOYLPHENOXY)ETHYL(HYDROXY)FORMAMIDE; N-[2-(3-benzoylphenoxy)ethyl]-N-hydroxyformamide; SB8; AC1NRD38; SCHEMBL6245513; BDBM21684; DB08524

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 5289330
TTD Drug ID: DMWMFTJ

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Staphylococcus Peptide deformylase (Stap-coc def)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GSK1322322	DM1EPMF	Bacterial infection	1A00-1C4Z	Phase 2	[2]
Actinonin	DMT4P89	N. A.	N. A.	Terminated	[3]
Formic Acid	DMNFZC6	Discovery agent	N.A.	Investigative	[4]
Double Oxidized Cysteine	DM6TU84	Discovery agent	N.A.	Investigative	[4]
Cysteinesulfonic Acid	DMXI8FP	Discovery agent	N.A.	Investigative	[4]
3-Sulfinoalanine	DMILTRN	N. A.	N. A.	Investigative	[4]
HYDROXY[3-(6-METHYLPYRIDIN-2-YL)PROPYL]FORMAMIDE	DMA4SIN	Discovery agent	N.A.	Investigative	[1]
[HYDROXY(3-PHENYLPROPYL)AMINO]METHANOL	DM7NXMB	Discovery agent	N.A.	Investigative	[1]
VRC3375	DM1QKVL	Discovery agent	N.A.	Investigative	[5]
N-alkyl urea hydroxamic acids	DM9T0OK	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Staphylococcus Peptide deformylase (Stap-coc def)	TTICO5G	DEF_STAAU	Inhibitor	[1]

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References

1	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
2	Peptide deformylase: a new target in antibacterial, antimalarial and anticancer drug discovery. Curr Med Chem. 2015;22(2):214-36.
3	Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor. Biochemistry. 2000 Feb 15;39(6):1256-62.
4	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
5	Peptide deformylase inhibitors as antibacterial agents: identification of VRC3375, a proline-3-alkylsuccinyl hydroxamate derivative, by using an integrated combinatorial and medicinal chemistry approach. Antimicrob Agents Chemother. 2004 Jan;48(1):250-61.
6	N-alkyl urea hydroxamic acids as a new class of peptide deformylase inhibitors with antibacterial activity. Antimicrob Agents Chemother. 2002 Sep;46(9):2752-64.