Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWS7O9)

Drug Name
PMID23099093C17d Drug Info
Synonyms GTPL8196; ZINC95559591; BDBM50401900
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
44465558
TTD Drug ID
DMWS7O9

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Investigative Drug(s)
Patented Agent(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting TGF-beta-activated kinase 1 (MAP3K7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
NG-25 DMC48D9 Discovery agent N.A. Investigative [2]
AZ-TAK1 DMD4LGN Mantle cell lymphoma 2A85.5 Investigative [3]
Drug(s) Targeting Inhibitor of nuclear factor kappa-B kinase (IKK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dihydrothieno [2,3-e]indazole derivative 1 DMUJ3XK N. A. N. A. Patented [4]
Dihydrothieno [2,3-e]indazole derivative 4 DMR4LPO N. A. N. A. Patented [4]
Dihydrothieno [2,3-e]indazole derivative 3 DM85VQR N. A. N. A. Patented [4]
Dihydrothieno [2,3-e]indazole derivative 2 DM0D3HU N. A. N. A. Patented [4]
Arsenite DMBCO4Q Discovery agent N.A. Investigative [5]
5-Bromo-6-methoxy-9H-beta-carboline DM157OQ Discovery agent N.A. Investigative [6]
MRT67307 DMYRCHG Discovery agent N.A. Investigative [7]
PS-1145 DMVUMWZ Multiple myeloma 2A83 Investigative [8]
4-hydroxy-2-nonenal DM2LJFZ Discovery agent N.A. Investigative [9]
BMS-345541 DM7D519 Arthritis FA20 Investigative [10]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting NF-kappa-B-activating kinase (TBK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID26293650-Compound-34 DMHXT12 N. A. N. A. Patented [11]
PMID26293650-Compound-35 DMPG8MF N. A. N. A. Patented [11]
Pyrimidinyl compound 4 DM53O9Y N. A. N. A. Patented [11]
Aminopyrimidine derivative 10 DM2TF64 N. A. N. A. Patented [11]
Pyrimidinyl compound 7 DMMYW2L N. A. N. A. Patented [11]
Pyrimidinyl compound 1 DMYKHQ8 N. A. N. A. Patented [11]
Aminopyrimidine derivative 7 DMW98RI N. A. N. A. Patented [11]
Pyrimidinyl compound 3 DMOE2FZ N. A. N. A. Patented [11]
Aminopyrimidine derivative 9 DM5VRXW N. A. N. A. Patented [11]
Pyrimidinyl compound 2 DM9TW5O N. A. N. A. Patented [11]
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Drug(s) Targeting Microtubule affinity regulating kinase 3 (MARK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
CBP-501 DMCWVPU Mesothelioma 2C51.2 Phase 1/2 [12]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Inhibitor of nuclear factor kappa-B kinase (IKK) TTRPDBG NOUNIPROTAC Inhibitor [1]
Microtubule affinity regulating kinase 3 (MARK3) TT3DCYJ MARK3_HUMAN Inhibitor [1]
NF-kappa-B-activating kinase (TBK1) TTH5TC2 TBK1_HUMAN Inhibitor [1]
TGF-beta-activated kinase 1 (MAP3K7) TTJQT60 M3K7_HUMAN Inhibitor [1]

References

1 Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKepsilon kinases. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7169-73.
2 Discovery of type II inhibitors of TGFbeta-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). J Med Chem. 2015 Jan 8;58(1):183-96.
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2082).
4 Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34.
5 Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase. J Biol Chem. 2000 Nov 17;275(46):36062-6.
6 Novel IKK inhibitors: beta-carbolines. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2419-22.
7 Novel cross-talk within the IKK family controls innate immunity. Biochem J. 2011 Feb 15;434(1):93-104.
8 Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.
9 IkappaB kinase, a molecular target for inhibition by 4-hydroxy-2-nonenal. J Biol Chem. 2001 May 25;276(21):18223-8.
10 A highly selective inhibitor of I kappa B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice. Arthritis Rheum. 2003 Sep;48(9):2652-9.
11 TBK1 inhibitors: a review of patent literature (2011 - 2014).Expert Opin Ther Pat. 2015;25(12):1385-96.
12 National Cancer Institute Drug Dictionary (drug id 577812).