Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWSA0V)

Drug Name

Patisiran Drug Info

Synonyms

Patisiran [INN]; Patisiran [USAN:INN]; UNII-50FKX8CB2Y; 50FKX8CB2Y; ALN-18328

Indication

Disease Entry	ICD 11	Status	REF
Amyloidosis	5D00	Approved	[1]
Hereditary amyloidosis	5D00.2	Approved	[2]
Amyloid cardiomyopathy	5D00.20	Phase 3	[3]
Transthyretin familial amyloid cardiomyopathy	5D00.20	Phase 3	[4]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Transthyretin messenger RNA (TTR mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vutrisiran	DMM1Z9G	Hereditary amyloidosis	5D00.2	Approved	[6]
Eplontersen	DMON9CY	Amyloid polyneuropathy	5D00.20	Approved	[7]
Revusiran	DM5E73H	Amyloidosis	5D00	Phase 3	[5]
ISIS-TTR	DM4U5NF	Amyloidosis	5D00	Phase 3	[8]
ALN-TTR01	DMCSEUY	Amyloidosis	5D00	Phase 1	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Transthyretin messenger RNA (TTR mRNA)	TTPOYU7	TTHY_HUMAN	Not Available	[5]

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References

1	FDA Approved Drug Products from FDA Official Website. 2018. Application Number: (ANDA) 210922.
2	2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	ClinicalTrials.gov (NCT01960348) APOLLO: The Study of an Investigational Drug, Patisiran (ALN-TTR02), for the Treatment of Transthyretin (TTR)-Mediated Amyloidosis. U.S. National Institutes of Health.
5	Clinical pipeline report, company report or official report of Alnylam Pharmaceuticals, Inc.
6	Clinical pipeline report, company report or official report of Alnylam Pharmaceuticals.
7	FDA Approved Drug Products from FDA Official Website. 2023. Application Number: 217388
8	Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011).
9	Safety and efficacy of RNAi therapy for transthyretin amyloidosis. N Engl J Med. 2013 Aug 29;369(9):819-29.