Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWT73D)

Drug Name

PMX-60056 Drug Info

Synonyms

PMX-150; PMX-60054; PMX-60065; PMX-60077; PMX-60079; PMX-60087; PMX-640; PMX-686; PMX-747; PMX-801; Heparin andlow molecular weight heparin (LMWH) reversing agents, PolyMedix

Indication

Disease Entry	ICD 11	Status	REF
Coagulation defect	3B10.0	Phase 2	[1]

Cross-matching ID

PubChem CID: 51349239
CAS Number: CAS 872454-31-4
TTD Drug ID: DMWT73D

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Antithrombin-III (ATIII)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[3]
Heparin Calcium	DMEVXY6	Coagulation defect	3B10.0	Approved	[3]
Sulodexide	DMNUC42	Tinnitus	MC41	Approved	[4]
Heparin Sodium	DM9KHZL	Coagulation defect	3B10.0	Approved	[5]
Unfractionated heparin	DMCWM03	Thrombosis	DB61-GB90	Phase 3	[6]
Heparin low molecular weight	DMGFULM	Thrombosis	DB61-GB90	Phase 3	[7]
KW-3357	DMP3GI2	Coagulation defect	3B10.0	Phase 3	[8]
O-desulfated heparin	DMJL4A7	Chronic obstructive pulmonary disease	CA22	Phase 2	[9]
M118	DML0I2Z	Acute coronary syndrome	BA41	Phase 2	[10]
MER-102	DME18UM	Thrombosis	DB61-GB90	Phase 1	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Antithrombin-III (ATIII)	TT4QPUL	ANT3_HUMAN	Antagonist	[2]

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References

1	ClinicalTrials.gov (NCT01312935) Reversal of Heparin in Patients Undergoing Percutaneous Coronary Intervention (PCI). U.S. National Institutes of Health.
2	Parenteral Anticoagulants: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Correction in: Chest. 2013 August; 144(2): 721.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Review of pharmacodynamics, pharmacokinetics, and therapeutic properties of sulodexide. Med Res Rev. 1998 Jan;18(1):1-20.
5	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2632).
6	Heparin with low affinity to antithrombin III inhibits the activation of prothrombin in normal plasma. Thromb Res. 1982 Nov 15;28(4):487-97.
7	Effects of low molecular weight heparin on a severely antithrombin III-decreased disseminated intravascular coagulation model in rabbits. Thromb Res. 1995 Dec 1;80(5):391-8.
8	Company report (kyowa-kirin)
9	Structural determinants of the capacity of heparin to inhibit the formation of the human amplification C3 convertase. J Clin Invest. 1981 Jan;67(1):223-8.
10	Clinical pipeline report, company report or official report of Momentapharma.
11	Clinical pipeline report, company report or official report of Merrion's GIPET technology.