Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWXI06)

Drug Name

2-[4-(2,4-Dichlorophenoxy)Phenoxy]Propanoic Acid Drug Info

Synonyms

Diclofop; 40843-25-2; Diclofop acid; DICHLORFOP ACID; Caswell No. 328B; 2-(4-(2,4-Dichlorophenoxy)phenoxy)propanoic acid; Diclofop [ANSI:BSI:ISO]; 2-[4-(2,4-Dichlorophenoxy)phenoxy]propanoic acid; HOE 21079; BRN 2338390; CHEBI:81909; OOLBCHYXZDXLDS-UHFFFAOYSA-N; Methyl 2-(4-(2,4-Dichlorophenyoxy)phenoxy)propanoate; HOE-021079; (RS)-2-(4-(2,4-Dichlorophenoxy)phenoxy)propionic acid; Methyl (RS)-2-(4-(2,4-Dichlorophenoxy)phenoxy)propionate; Propanoic acid, 2-(4-(2,4-dichlorophenoxy)phenoxy)-; Propanoic acid, 2-[4-(2,4-dichloro

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 38687
ChEBI ID: CHEBI:81909
CAS Number: CAS 40843-25-2
TTD Drug ID: DMWXI06

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Acetyl-CoA carboxylase 2 (ACACB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metformin	DM89QE1	Colorectal carcinoma		Approved	[2]
PF-05175157	DMLQ3OK	Type-2 diabetes	5A11	Phase 2	[3]
Axokine	DMT5O8I	Obesity	5B81	Discontinued in Phase 3	[4]
CP-640186	DMO0PS9	Discovery agent	N.A.	Investigative	[5]
A-80040	DML20N9	Discovery agent	N.A.	Investigative	[6]
AC-8632	DM09BJ4	Parkinson disease	8A00.0	Investigative	[3]
QLT-091382	DMWOSFJ	Sebaceous gland disease	EM0Z	Investigative	[3]
Soraphen A	DM18IKZ	Discovery agent	N.A.	Investigative	[7]
------------------------------------------------------------------------------------


⏷ Show the Full List of 8 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Acetyl-CoA carboxylase 2 (ACACB)	TTY84UG	ACACB_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

References

1	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
2	AMP-activated protein kinase-dependent and -independent mechanisms underlying in vitro antiglioma action of compound C. Biochem Pharmacol. 2009 Jun 1;77(11):1684-93.
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1264).
4	Obesity: pathophysiology and clinical management. Curr Med Chem. 2009;16(4):506-21.
5	(4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6645-8.
6	Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acet... J Med Chem. 2006 Jun 29;49(13):3770-3.
7	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.