Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWZT3N)

Drug Name

ION839 Drug Info

Synonyms

AZD2693

Indication

Disease Entry	ICD 11	Status	REF
Non-alcoholic steatohepatitis	DB92.1	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 messenger RNA (PNPLA3 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AMG 609	DMVCA06	Non-alcoholic steatohepatitis	DB92.1	Phase 1	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 messenger RNA (PNPLA3 mRNA)	TTEUAEH	PLPL3_HUMAN	Not Available	[2]

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References

1	ClinicalTrials.gov (NCT05809934) A Randomised, Double-blind, Placebo-controlled, Multi-centre Phase 2b Study to Evaluate the Efficacy, Safety and Tolerability of AZD2693 in Participants With Non-cirrhotic Non-alcoholic Steatohepatitis (NASH) With Fibrosis Who Are Carriers of the PNPLA3 rs738409 148M Risk Allele. U.S.National Institutes of Health.
2	Clinical pipeline report, company report or official report of Ionis
3	Insights into the molecular targets and emerging pharmacotherapeutic interventions for nonalcoholic fatty liver disease. Metabolism. 2022 Jan;126:154925.