General Information of Drug (ID: DMX1OI8)

Drug Name
ISIS 11158 Drug Info
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
TTD Drug ID
DMX1OI8

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ISIS 1570 DMJ9G23 Lleum inflammation 1A40.0 Approved [2]
Alicaforsen DMQ509J Lleum inflammation 1A40.0 Phase 3 [3]
INXC-ICAM1 DMODQW0 Transplant rejection NE84 Terminated [4]
A-286982 DM98VFW Discovery agent N.A. Investigative [5]
ISIS 11159 DM9V6FW Discovery agent N.A. Investigative [1]
ISIS 3224 DMAFEYG Discovery agent N.A. Investigative [1]
ISIS 1931 DMBMQNI Discovery agent N.A. Investigative [2]
PIPERROLEIN B DMRVHWZ Discovery agent N.A. Investigative [6]
ISIS 2974 DM7K19L Discovery agent N.A. Investigative [2]
Dehydropipernonaline DMIOA9M Discovery agent N.A. Investigative [6]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
ICAM1 messenger RNA (ICAM1 mRNA) TTA1L39 ICAM1_HUMAN Not Available [1]

References

1 US patent application no. 5,789,573, Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2.
2 US patent application no. 6,300,491, Oligonucleotide inhibition of cell adhesion.
3 Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2009).
4 ISIS 2302. INXC ICAM1, Oligo-TCS. Drugs R D. 1999 Jan;1(1):85-6.
5 Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5269-73.
6 Alkamides from the fruits of Piper longum and Piper nigrum displaying potent cell adhesion inhibition. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4544-6.