Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMX27IT)

• Drug Name: DTRM-555 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Chronic lymphocytic leukaemia	2A82.0	Phase 2	[1]

• Cross-matching ID: TTD Drug ID: DMX27IT

Molecule-Related Drug Atlas

Drug(s) Targeting Tyrosine-protein kinase BTK (ATK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[2]
Acalabrutinib	DM7GCVW	leukaemia	2A60-2B33	Approved	[3]
Zanubrutinib	DMJWRQP	Mantle cell lymphoma	2A85.5	Approved	[4]
Pirtobrutinib	DMRG1X3	Non-hodgkin lymphoma	2B33.5	Approved	[5]
GDC-0853	DMBEL3Q	Multiple sclerosis	8A40	Phase 3	[6]
ICP-022	DMU72KL	Chronic lymphocytic leukaemia	2A82.0	Phase 3	[7]
Tolebrutinib	DML19V6	Multiple sclerosis	8A40	Phase 3	[8]
CC-292	DMJR9H0	Chronic lymphocytic leukaemia	2A82.0	Phase 2	[9]
BMS-986142	DMZB8AJ	Rheumatoid arthritis	FA20	Phase 2	[6]
LOU064	DME8O5K	Chronic idiopathic urticaria	EB00.1	Phase 2	[10]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tyrosine-protein kinase BTK (ATK)	TTGM6VW	BTK_HUMAN	Inhibitor	[1]

References

• [1] ClinicalTrials.gov (NCT04305444) Study of a Triple Combination Therapy, DTRM-555, in Patients With R/R CLL or R/R Non-Hodgkin's Lymphomas. U.S. National Institutes of Health.
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1948).
• [3] 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
• [4] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
• [5] Targeting BTK in CLL: Beyond Ibrutinib. Curr Hematol Malig Rep. 2019 Jun;14(3):197-205.
• [6] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [7] Clinical pipeline report, company report or official report of InnoCare Pharma.
• [8] Safety and efficacy of tolebrutinib, an oral brain-penetrant BTK inhibitor, in relapsing multiple sclerosis: a phase 2b, randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2021 Sep;20(9):729-738.
• [9] Inhibition of Btk with CC-292 provides early pharmacodynamic assessment of activity in mice and humans. J Pharmacol Exp Ther. 2013 Aug;346(2):219-28.
• [10] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)