Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMX41ZF)

Drug Name

T863 Drug Info

Synonyms

701232-20-4; DGAT-3; T863; DGAT-1 inhibitor; UNII-OF68Z8HK6V; OF68Z8HK6V; trans-4-[4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexaneacetic acid; T-863; 2-(4-(4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl)cyclohexyl)acetic acid; trans-4-(4-(4-amino-7,7-dimethyl-7h-pyrimido(4,5-b)(1,4)oxazin-6-yl)phenyl)cyclohexaneacetic acid; Cyclohexaneacetic acid, 4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]-, trans-; Cyclohexaneacetic acid, 4-(4-(4-amino-7,7-di

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 9865421
CAS Number: CAS 701232-20-4
TTD Drug ID: DMX41ZF

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Diacylglycerol acyltransferase 1 (DGAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[3]
LCQ908	DMFLJHQ	Familial chylomicronemia syndrome	5C80	Phase 3	[4]
AZD7687	DMS9I6A	Diabetic complication	5A2Y	Phase 1	[5]
P-7435	DMNZQU5	Diabetic complication	5A2Y	Phase 1	[6]
PMID25470667-Compound-Figure4-1A	DMMVQW8	N. A.	N. A.	Patented	[2]
Azole derivative 7	DMVUJGI	N. A.	N. A.	Patented	[2]
Carbamide derivative 3	DM4ISCQ	N. A.	N. A.	Patented	[2]
Benzamide derivative 19	DM5YNTM	N. A.	N. A.	Patented	[2]
Lactam derivative 5	DMX5FYZ	N. A.	N. A.	Patented	[2]
Pyridine-carboximide derivative 2	DMHXWZB	N. A.	N. A.	Patented	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Diacylglycerol acyltransferase 1 (DGAT1)	TTF8P9I	DGAT1_HUMAN	Inhibitor	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7828).
2	Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58.
3	In vitro inhibition of diacylglycerol acyltransferase by prenylflavonoids from Sophora flavescens. Planta Med. 2004 Mar;70(3):258-60.
4	DGAT1 inhibitors as anti-obesity and anti-diabetic agents. Curr Opin Drug Discov Devel. 2010 Jul;13(4):489-96.
5	Clinical pipeline report, company report or official report of AstraZeneca (2011).
6	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033014)