Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMX9K3W)

Drug Name

Cetraxal Otic Drug Info

Synonyms

Ciprofloxacin otic

Indication

Disease Entry	ICD 11	Status	REF
Otitis externa	AA00-AA13	Phase 3	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Streptococcus Topoisomerase IV A (Stre-coc parC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Premafloxacin	DMC4W03	Discovery agent	N.A.	Investigative	[2]
Pumiliotoxin 251D	DMY2F6T	Bacterial infection	1A00-1C4Z	Investigative	[3]
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Drug(s) Targeting Haemophilus influenzae DNA gyrase A (Hae-influ gyrA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ACH-702	DMMNQE3	Bacterial infection	1A00-1C4Z	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Haemophilus influenzae DNA gyrase A (Hae-influ gyrA)	TTE72ID	GYRA_HAEIN	Modulator	[1]
Streptococcus Topoisomerase IV A (Stre-coc parC)	TT1WJCI	PARC_STRPN	Modulator	[1]

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References

1	DNA topoisomerases and their poisoning by anticancer and antibacterial drugs. Chem Biol. 2010 May 28;17(5):421-33.
2	Alteration of Escherichia coli topoisomerase IV to novobiocin resistance. Antimicrob Agents Chemother. 2003 Mar;47(3):941-7.
3	How many modes of action should an antibiotic have Curr Opin Pharmacol. 2008 Oct;8(5):564-73.
4	In vitro antituberculosis activities of ACH-702, a novel isothiazoloquinolone, against quinolone-susceptible and quinolone-resistant isolates. Antimicrob Agents Chemother. 2010 Aug;54(8):3478-80.