Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXA4HY)

Drug Name
Poly IC-poly arginine Drug Info
Synonyms Poly-ICR vaccine adjuvant, Akela; Poly-ICR vaccine adjuvant, Nventa; Poly(inosinic-cytidylic) acid-poly arginine
Indication
Disease Entry ICD 11 Status REF
Keratosis ED56 Investigative [1]
Cross-matching ID
TTD Drug ID
DMXA4HY

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Toll-like receptor 3 (TLR3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rintatolimod DMYX7VI Human immunodeficiency virus infection 1C62 Phase 3 [2]
Poly-ICLC DM2570B Glioblastoma multiforme 2A00.0 Phase 2 [3]
BCG65-E7 DMAMFXC Anal intraepithelial neoplasia 2E92.5 Discontinued in Phase 3 [4]
IPH-3102 DMY3BMC Solid tumour/cancer 2A00-2F9Z Terminated [5]
polyIC DMV486E Discovery agent N.A. Investigative [6]
Anti-TLR3 mabs DMN76A4 Autoimmune diabetes 5A10 Investigative [1]
Poly-ICR DMUMJ7B Keratosis ED56 Investigative [1]
⏷ Show the Full List of 7 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Toll-like receptor 3 (TLR3) TTD24Y0 TLR3_HUMAN Not Available [1]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1753).
2 A double-blind, placebo-controlled, randomized, clinical trial of the TLR-3 agonist rintatolimod in severe cases of chronic fatigue syndrome. PLoS One. 2012;7(3):e31334.
3 Toll like receptor-3 ligand poly-ICLC promotes the efficacy of peripheral vaccinations with tumor antigen-derived peptide epitopes in murine CNS tumor models. J Transl Med. 2007 Feb 12;5:10.
4 Serological response to an HPV16 E7 based therapeutic vaccine in women with high-grade cervical dysplasia. Gynecol Oncol. 2010 Feb;116(2):208-12.
5 Trial Watch: Experimental Toll-like receptor agonists for cancer therapy. Oncoimmunology. 2012 August 1; 1(5): 699-716.
6 Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature. 2001 Oct 18;413(6857):732-8.