Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXCD69)

Drug Name
CEP1347 Drug Info
Synonyms AC1L31ZX; SCHEMBL1649555; ZINC103589452; DB05403
Indication
Disease Entry ICD 11 Status REF
Asthma CA23 Phase 2/3 [1]
Cross-matching ID
PubChem CID
9917013
CAS Number
CAS 156177-65-0
TTD Drug ID
DMXCD69

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Mixed lineage kinase 1 (MAP3K9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
URMC-099 DMCJXWK Discovery agent N.A. Investigative [3]
CEP-5104 DMV43GY Discovery agent N.A. Investigative [4]
CEP-6331 DMNXBTD Discovery agent N.A. Investigative [4]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Mixed lineage kinase 1 (MAP3K9) TTUNSIX M3K9_HUMAN Inhibitor [2]

References

1 Targeting the JNK signaling pathway for stroke and Parkinson's diseases therapy. Curr Drug Targets CNS Neurol Disord. 2005 Feb;4(1):63-7.
2 Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci. 2002 Jan;23(1):40-5.
3 Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3. J Med Chem. 2013 Oct 24;56(20):8032-48.
4 Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-linea... J Med Chem. 2008 Sep 25;51(18):5680-9.