Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXIKYR)

Drug Name
APTO-253 Drug Info
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
Cross-matching ID
PubChem CID
11960271
CAS Number
CAS 916151-99-0
TTD Drug ID
DMXIKYR

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Kruppel like factor 4 (KLF4) TTTI53X KLF4_HUMAN Inhibitor [2]

References

1 ClinicalTrials.gov (NCT02267863) A Study of APTO-253 HCl in Patients With Relapsed or Refractory Hematologic Malignancies. U.S. National Institutes of Health.
2 Phase 1 study of APTO-253 HCl, an inducer of KLF4, in patients with advanced or metastatic solid tumors. Invest New Drugs. 2015 Oct;33(5):1086-92.