Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXLVDT)

Drug Name

Lasmiditan Drug Info

Synonyms

COL-144; LY-573144; Migraine therapy, CoLucid

Indication

Disease Entry	ICD 11	Status	REF
Migraine	8A80	Approved	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting 5-HT 1F receptor (HTR1F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metergolin	DMJFP6G	Hyperprolactinaemia	5A60.1	Approved	[2]
LY-334370	DM43O9N	Migraine	8A80	Phase 2	[3]
5-CT	DM260KD	Discovery agent	N.A.	Investigative	[2]
TFMPP	DMAC8TP	Discovery agent	N.A.	Investigative	[4]
1-naphthylpiperazine	DM6BIWK	Discovery agent	N.A.	Investigative	[2]
BRL-15572	DMM61Y2	Discovery agent	N.A.	Investigative	[5]
2-methyl-5-HT	DM1S5CB	N. A.	N. A.	Investigative	[4]
alpha-methyl-5-HT	DMCAYXF	Discovery agent	N.A.	Investigative	[4]
WAY-466	DMMOH51	Discovery agent	N.A.	Investigative	[6]
[125I]LSD	DMP69QG	Discovery agent	N.A.	Investigative	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
2	Cloning and characterization of the guinea pig 5-HT1F receptor subtype: a comparison of the pharmacological profile to the human species homolog. Neuropharmacology. 1997 Apr-May;36(4-5):569-76.
3	Selective seratonin 1F (5-HT(1F)) receptor agonist LY334370 for acute migraine: a randomised controlled trial. Lancet. 2001 Oct 13;358(9289):1230-4.
4	Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase. Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):408-12.
5	SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):312-20.
6	Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists. J Med Chem. 2005 Jan 27;48(2):353-6.
7	Isolation of a mouse "5HT1E-like" serotonin receptor expressed predominantly in hippocampus. J Biol Chem. 1992 Oct 5;267(28):19761-4.