Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXM7JR)

Drug Name

daminozide Drug Info

Synonyms

DMASA; SADH; B 995; Alar; Kylar; B-NINE

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Lysine-specific demethylase 2A (KDM2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IOX2	DMQ0X7I	Discovery agent	N.A.	Investigative	[2]
------------------------------------------------------------------------------------

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histone lysine demethylase PHF8 (PHF8)	TT81PFE	PHF8_HUMAN	Inhibitor	[1]
Lysine-specific demethylase 2A (KDM2A)	TT8XTY2	KDM2A_HUMAN	Inhibitor	[1]
Lysine-specific demethylase 7A (KDM7A)	TT0NYMP	KDM7A_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

References

1	Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J Med Chem. 2012 Jul 26;55(14):6639-43.
2	Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. ACS Chem Biol. 2013 Jul 19;8(7):1488-96.