Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXSRPH)

Drug Name
Macrocycle derivative 14 Drug Info
Synonyms PMID26161698-Compound-7
Cross-matching ID
PubChem CID
136644752
TTD Drug ID
DMXSRPH

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Preclinical Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Cyclin-dependent kinase 8 (CDK8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
SEL120 DMHCUZV Acute myeloid leukaemia 2A60 Phase 1 [2]
Tricyclic benzimidazole derivative 1 DM5SD9E N. A. N. A. Patented [1]
CCT251545 DMNA9KW Colorectal cancer 2B91.Z Preclinical [3]
Oxindole 94 DMPFD6Y Pain MG30-MG3Z Investigative [4]
Oxindole 16 (compound 3) DMM5208 Discovery agent N.A. Investigative [4]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cyclin-dependent kinase 8 (CDK8) TTBJR4L CDK8_HUMAN Inhibitor [1]

References

1 Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70.
2 Clinical pipeline report, company report or official report of Ryvu Therapeutics.
3 Kinase inhibitors: the road ahead. Nat Rev Drug Discov. 2018 May;17(5):353-377.
4 Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci. 2002 Sep;23(9):417-25.