Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMY1CP9)

Drug Name

GLG-801 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Chronic lymphocytic leukaemia	2A82.0	Phase 1/2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acitretin	DM8BKU9	Psoriasis vulgaris	EA90	Approved	[2]
Napabucasin	DMDZ6Q3	Colorectal cancer	2B91.Z	Phase 3	[1]
Golotimod	DMKZN3A	Immune System disease	4A01-4B41	Phase 2	[3]
NT219	DMOYS1N	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[4]
WP-1066	DMUGHWR	Recurrent glioblastoma	2A00.00	Phase 1/2	[1]
Atiprimod	DM84YEC	Multiple myeloma	2A83	Phase 1/2	[5]
OPB-31121	DM6VGO3	Hepatocellular carcinoma	2C12.02	Phase 1/2	[6]
IMX-110	DMNHZS4	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[1]
OPB-51602	DM760FA	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]
TAK-114	DMTXE19	Ulcerative colitis	DD71	Phase 1	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Signal transducer and activator of transcription 3 (STAT3)	TTH8FZW	STAT3_HUMAN	Inhibitor	[1]

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Effects of acitretin on the expression of signaling pathway-related genes in epidermal squamous-cell carcinoma cells. Zhonghua Zhong Liu Za Zhi. 2006 Jan;28(1):21-4.
3	National Cancer Institute Drug Dictionary (drug id 617379).
4	Clinical pipeline report, company report or official report of Purple Biotech.
5	Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.
6	OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells. Cancer Lett. 2013 Jul 10;335(1):145-52.
7	Phase I and biomarker study of OPB-51602, a novel signal transducer and activator of transcription (STAT) 3 inhibitor, in patients with refractory solid malignancies. Ann Oncol. 2015 May;26(5):998-1005.
8	Clinical pipeline report, company report or official report of Gastroenterology.