General Information of Drug (ID: DMY1OG7)

Drug Name
ALM-301 Drug Info
Synonyms Akt inhibitors (cancer), Almac
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Investigative [1]
Cross-matching ID
TTD Drug ID
DMY1OG7

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [2]
Enzastaurin DM5H0R9 Diffuse large B-cell lymphoma 2A81 Phase 3 [2]
GDC-0068 DMWBZJD Breast cancer 2C60-2C65 Phase 3 [2]
CI-1033 DMSI8N3 Lymphoma 2A80-2A86 Phase 2 [3]
CMX-2043 DMPSCVY Cardiac disease BA00-BE2Z Phase 2 [4]
ARQ 092 DM5WK0J Proteus syndrome LD2C Phase 2 [5]
GSK2110183 DMZHB37 leukaemia 2A60-2B33 Phase 2 [1]
RX-0201 DMTBAV3 Pancreatic cancer 2C10 Phase 2 [6]
PTX-200 DM0ZIT2 Breast cancer 2C60-2C65 Phase 2 [2]
Triciribine prodrug DMBN1XS Solid tumour/cancer 2A00-2F9Z Phase 1/2 [1]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
RAC-alpha serine/threonine-protein kinase (AKT1) TTWTSCV AKT1_HUMAN Inhibitor [1]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1479).
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.
4 Pre-clinical and Clinical Safety Studies of CMX-2043: a cytoprotective lipoic acid analogue for ischaemia-reperfusion injury. Basic Clin Pharmacol Toxicol. 2014 Nov;115(5):456-64.
5 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6 CenterWatch. Drugs in Clinical Trials Database. CenterWatch. 2008.