Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMY43FU)

Drug Name

PO3 2-Leu-Nal-O-3K Drug Info

Synonyms

CHEMBL280917

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Endothelin-converting enzyme 1 (ECE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SCH-54470	DMEWLZ7	N. A.	N. A.	Terminated	[2]
LY-292223	DML36ZE	Discovery agent	N.A.	Investigative	[3]
CGS 35066	DMCHT27	Discovery agent	N.A.	Investigative	[4]
PO3 2-Nle-Trp-O-3K	DMW1XY4	Discovery agent	N.A.	Investigative	[1]
PMID19899765C22	DMBTV20	Discovery agent	N.A.	Investigative	[2]
PO3 2-Leu-Trp-O-3K	DM3O78D	Discovery agent	N.A.	Investigative	[1]
5-(2-hydroxyethyl)nonane-1,9-diol	DMHBD1T	Discovery agent	N.A.	Investigative	[5]
PO3 2-Ile-Trp-O-3K	DMQMDSG	Discovery agent	N.A.	Investigative	[1]
PD159790	DM6RVTO	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Endothelin-converting enzyme 1 (ECE1)	TTQ9RYT	ECE1_HUMAN	Inhibitor	[1]

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References

1	Aminophosphonate endothelin converting enzyme inhibitors: potency-enhancing and selectivity-improving modifications of phosphoramidon, Bioorg. Med. Chem. Lett. 4(10):1257-1262 (1994).
2	Phosphinic tripeptides as dual angiotensin-converting enzyme C-domain and endothelin-converting enzyme-1 inhibitors. J Med Chem. 2010 Jan 14;53(1):208-20.
3	Endothelin-converting enzyme-1 inhibition and growth of human glioblastoma cells. J Med Chem. 2005 Jan 27;48(2):483-98.
4	The therapeutic potential of endothelin-1 receptor antagonists and endothelin-converting enzyme inhibitors on the cardiovascular system. Expert Opin Investig Drugs. 2002 Nov;11(11):1537-52.
5	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
6	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1615).