Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMY57L0)

Drug Name

melanin-concentrating hormone Drug Info

Synonyms

Melanin-concentrating hormone; Melanin concentrating hormone; GTPL1298

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting Melanin-concentrating hormone receptor 1 (MCHR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BMS-830216	DMCW71N	Obesity	5B81	Phase 1	[4]
AZD1979	DMQ1OX4	Obesity	5B81	Phase 1	[5]
PMID25522065-Compound-27	DMXN4KB	N. A.	N. A.	Patented	[6]
PMID25522065-Compound-29	DMBNAK9	N. A.	N. A.	Patented	[6]
PMID25522065-Compound-34	DMZDIRQ	N. A.	N. A.	Patented	[6]
PMID25522065-Compound-39	DM5YMQH	N. A.	N. A.	Patented	[6]
PMID25522065-Compound-40	DMCIQ01	N. A.	N. A.	Patented	[6]
PMID25522065-Compound-11	DM410Z6	N. A.	N. A.	Patented	[6]
PMID25522065-Compound-50	DMBWA0V	N. A.	N. A.	Patented	[6]
PMID25522065-Compound-12	DMVKO9C	N. A.	N. A.	Patented	[6]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Targeting Melanin-concentrating hormone receptor 2 (MCHR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ATC0065	DMJNQ5G	Discovery agent	N.A.	Investigative	[7]
PMID22123324C38	DMZ5BHX	Discovery agent	N.A.	Investigative	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Melanin-concentrating hormone receptor 1 (MCHR1)	TTX4RTB	MCHR1_HUMAN	Agonist	[2]
Melanin-concentrating hormone receptor 2 (MCHR2)	TTS17MG	MCHR2_HUMAN	Agonist	[3]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1298).
2	[125I]-S36057: a new and highly potent radioligand for the melanin-concentrating hormone receptor. Br J Pharmacol. 2001 Jun;133(3):371-8.
3	Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7564-9.
4	2011 Pipeline of Bristol-Myers Squibb.
5	Phase I clinical trial of AZD1979 for treating obesity. AstraZeneca plc
6	Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207.
7	Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagoni... J Pharmacol Exp Ther. 2005 May;313(2):831-9.
8	Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2. Bioorg Med Chem Lett. 2012 Jan 1;22(1):363-6.