Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMY5JEP)

• Drug Name: Mezlocillin Drug Info
• Synonyms: Mezlin; Mezlocilina; Mezlocillinum; Mezlocillin (USAN/INN); (2S,5R,6R)-3,3-dimethyl-6-[[(2R)-2-[(3-methylsulfonyl-2-oxoimidazolidine-1-carbonyl)amino]-2-phenylacetyl]amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-3,3-dimethyl-6-{[(2R)-2-({[3-(methylsulfonyl)-2-oxoimidazolidin-1-yl]carbonyl}amino)-2-phenylacetyl]amino}-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 6beta-{(2R)-2-[3-(methanesulfonyl)-2-oxoimidazolidine-1-carboxamido]-2-phenylacetamido}-2,2-dimethylpenam-3alpha-carboxylic acid; 6beta-{(2R)-2-[3-(methanesulfonyl)-2-oxoimidazolidine-1-carboxamido]-2-phenylacetamido}penicillanic acid

Indication

Disease Entry	ICD 11	Status	REF
Acute gonococcal cervicitis		Approved	[1]
Aspiration pneumonia		Approved	[1]
Bacteremia	1A73	Approved	[1]
Urinary tract infection	GC08	Approved	[2]

• Therapeutic Class: Antibiotics
• Cross-matching ID:
  PubChem CID: 656511
  ChEBI ID: CHEBI:6919
  CAS Number: CAS 51481-65-3
  TTD Drug ID: DMY5JEP

Molecule-Related Drug Atlas

Drug(s) Targeting Bacterial Penicillin binding protein 3 (Bact mrcA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aztreonam	DMDNJHG	Bacterial infection	1A00-1C4Z	Approved	[4]
Cefmetazole	DM42W1B	Bacterial infection	1A00-1C4Z	Approved	[5]
Cefotiam	DMF5HU6	Respiratory tract infection	CA45	Approved	[6]
Latamoxef	DMANL0D	Bacterial infection	1A00-1C4Z	Approved	[5]
Moxalactam Disodium	DMYKUNR	Bacterial infection	1A00-1C4Z	Approved	[7]
Cefmenoxime	DMPLY7B	Bacterial infection	1A00-1C4Z	Approved	[8]
Benzylpenicillin	DMS9503	Actinomycosis		Phase 3	[9]
LYS228	DM23Y6K	Urinary tract infection	GC08	Phase 2	[10]
Cephalosporin C	DMYW3ZG	Discovery agent	N.A.	Investigative	[11]
PCNOTAXIME GROUP	DMGS6YH	Discovery agent	N.A.	Investigative	[12]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Penicillin binding protein 3 (Bact mrcA)	TT85JMW	FTSI_ECOLI	Binder	[3]

References

• [1] Mezlocillin FDA Label
• [2] FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 050549.
• [3] Bactericidal effect of piperacillin alone and combined. Presse Med. 1986 Dec 20;15(46):2297-302.
• [4] Penicillin-binding protein PBP2 of Escherichia coli localizes preferentially in the lateral wall and at mid-cell in comparison with the old cell pole. Mol Microbiol. 2003 Jan;47(2):539-47.
• [5] Clinical relevance of antibiotic-induced endotoxin release in patients undergoing hepatic resection. World J Surg. 1999 Jan;23(1):75-9.
• [6] Genetic analyses of beta-lactamase negative ampicillin-resistant strains of Haemophilus influenzae isolated in Okinawa, Japan. Jpn J Infect Dis. 2006 Feb;59(1):36-41.
• [7] Moxalactam (6059-S), a new 1-oxa-beta-lactam: binding affinity for penicillin-binding proteins of Escherichia coli K-12.
• [8] In vitro evaluation of E1040, a new cephalosporin with potent antipseudomonal activity. Antimicrob Agents Chemother. 1988 May;32(5):693-701.
• [9] Association of amino acid substitutions in penicillin-binding protein 3 with beta-lactam resistance in beta-lactamase-negative ampicillin-resistant Haemophilus influenzae. Antimicrob Agents Chemother. 2001 Jun;45(6):1693-9.
• [10] Mode of Action of the Monobactam LYS228 and Mechanisms Decreasing In Vitro Susceptibility in Escherichia coli and Klebsiella pneumoniae. Antimicrob Agents Chemother. 2018 Sep 24;62(10):e01200-18.
• [11] DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
• [12] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.