Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMY65ZP)

Drug Name

LICOAGROCHALCONE A Drug Info

Synonyms

licoagrochalcone A; 3-Prenyl-4,2',4'-trihydroxychalcone; CHEMBL229885; 2',4,4'-trihydroxy-3-prenylchalcone; 202815-28-9; SCHEMBL632907; LMPK12120068; BDBM50212400; ACM202815289; (E)-2',4,4'-Trihydroxy-3-prenylchalcone; 1-(2,4-Dihydroxyphenyl)-3-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]-prop-2-en-1-one

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 11099375
CAS Number: CAS 202815-28-9
TTD Drug ID: DMY65ZP

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting PTPN1 messenger RNA (PTPN1 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[2]
TRYPAN BLUE	DM4NTMO	Ophthalmic surgery injury	PK97	Approved	[3]
URSOLIC ACID	DM4SOAW	Metabolic syndrome x	5C50-5D2Z	Phase 2	[4]
ISIS 113715	DMUPD4G	Type-2 diabetes	5A11	Phase 2	[5]
ISIS-PTP1Brx	DMJGVXT	Type-2 diabetes	5A11	Phase 2	[6]
ERTIPROTAFIB	DMJXEV7	Type-2 diabetes	5A11	Terminated	[7]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[8]
B-Octylglucoside	DMMO75G	Discovery agent	N.A.	Investigative	[8]
2-Methyl-2,4-Pentanediol	DMD45CU	Discovery agent	N.A.	Investigative	[8]
Double Oxidized Cysteine	DM6TU84	Discovery agent	N.A.	Investigative	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
PTPN1 messenger RNA (PTPN1 mRNA)	TTELIN2	PTN1_HUMAN	Inhibitor	[1]

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References

1	Isoprenylated flavonoids from the stem bark of Erythrina abyssinica. J Nat Prod. 2007 Jun;70(6):1039-42.
2	Periodinates: a new class of protein tyrosine phosphatase inhibitors. Bioorg Med Chem Lett. 1999 Feb 8;9(3):353-6.
3	Evans Blue and other dyes as protein tyrosine phosphatase inhibitors. Bioorg Med Chem Lett. 2004 Apr 19;14(8):1923-6.
4	Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6745-9.
5	Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2009).
6	Clinical pipeline report, company report or official report of ISIS Pharmaceuticals.
7	2-O-carboxymethylpyrogallol derivatives as PTP1B inhibitors with antihyperglycemic activity. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5357-60.
8	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.