General Information of Drug (ID: DMY7R3X)

Drug Name
AZD-1678 Drug Info
Synonyms CCR4 antagonist (asthma), AstraZeneca
Indication
Disease Entry ICD 11 Status REF
Asthma CA23 Preclinical [1]
Cross-matching ID
PubChem CID
23585443
TTD Drug ID
DMY7R3X

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mogamulizumab DMISH0Z Mycosis fungoides 2B01 Approved [3]
RPT193 DMZJ0N3 Asthma CA23 Phase 2 [4]
FLX475 DMI7S39 Solid tumour/cancer 2A00-2F9Z Phase 1/2 [5]
ATLCAR.CD30.CCR4 cells DM3IPSX Immune System disease 4A01-4B41 Phase 1 [6]
GSK-2239633 DMUNVXR Asthma CA23 Phase 1 [7]
N-(4-tert-butylthiazol-2-yl)-1H-indol-4-amine DMFUBQ8 Discovery agent N.A. Investigative [8]
AT-008 DMODLPS Autoimmune diabetes 5A10 Investigative [7]
4-tert-butyl-N-phenylthiazol-2-amine DM5CPBK Discovery agent N.A. Investigative [8]
4-methyl-N-(naphthalen-1-yl)thiazol-2-amine DMFRASQ Discovery agent N.A. Investigative [8]
4-tert-butyl-N-(naphthalen-1-yl)oxazol-2-amine DM5U6ZW Discovery agent N.A. Investigative [8]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
C-C chemokine receptor type 4 (CCR4) TT7HQD0 CCR4_HUMAN Antagonist [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030818)
2 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030818)
3 Mogamulizumab, a humanized mAb against C-C chemokine receptor 4 for the potential treatment of T-cell lymphomas and asthma. Curr Opin Mol Ther. 2010 Dec;12(6):770-9.
4 ClinicalTrials.gov (NCT05399368) A Phase 2 Study to Evaluate the Efficacy and Safety of RPT193 as Monotherapy in Adults With Moderate-to-Severe Atopic Dermatitis. U.S.National Institutes of Health.
5 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6 ClinicalTrials.gov (NCT03602157) Study of CAR-T Cells Expressing CD30 and CCR4 for r/r CD30+ HL and NHL
7 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 61).
8 Optimization of 2-aminothiazole derivatives as CCR4 antagonists. Bioorg Med Chem Lett. 2006 May 15;16(10):2800-3.