Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYAS2V)

Drug Name

6-(4-Methylpiperazin-1-yl)pyrimidine-2,4-diamine Drug Info

Synonyms

CHEMBL473662; 6-(4-Methylpiperazin-1-yl)pyrimidine-2,4-diamine; BAS 06575347; AC1LFG9R; 2,4-Pyrimidinediamine, 6-(4-methyl-1-piperazinyl)-; SCHEMBL2169898; MolPort-002-005-545; ZINC205303; BDBM50304501; CCG-24528; AKOS000670805; 4940-96-9; VU0047515-1

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 753256
TTD Drug ID: DMYAS2V

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Histamine H4 receptor (H4R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PF-3893787	DMC2FAL	Atopic dermatitis	EA80	Phase 2	[2]
JNJ-38518168	DM9UMIO	Plaque psoriasis	EA90.0	Phase 2	[3]
UR-63325	DME6X27	Allergic rhinitis	CA08.0	Phase 2	[4]
Thioperamide	DM8S593	Cognitive impairment	6D71	Terminated	[5]
2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole	DMZVBPG	Discovery agent	N.A.	Investigative	[6]
impromidine	DMTDRPM	Discovery agent	N.A.	Investigative	[7]
burimamide	DMZ2VYG	Discovery agent	N.A.	Investigative	[8]
Imetit	DMMJ6NS	Discovery agent	N.A.	Investigative	[9]
[125I]iodophenpropit	DMN4ABU	Discovery agent	N.A.	Investigative	[10]
(R)-alpha-methylhistamine	DMKAW4P	Discovery agent	N.A.	Investigative	[11]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histamine H4 receptor (H4R)	TTXJ178	HRH4_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

References

1	2,4-Diaminopyrimidines as histamine H4 receptor ligands--Scaffold optimization and pharmacological characterization. Bioorg Med Chem. 2009 Oct 15;17(20):7186-96.
2	Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: a novel histamine H4 receptor antagonist. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6596-602.
3	The histamine H4 receptor: from orphan to the clinic. Front Pharmacol. 2015; 6: 65.
4	Azines as histamine H4 receptor antagonists. Front Biosci (Schol Ed). 2012 Jan 1;4:967-87.
5	Role of histamine in short- and long-term effects of methamphetamine on the developing mouse brain. J Neurochem. 2008 Nov;107(4):976-86.
6	Synthesis and structure-activity relationships of N-aryl-piperidine derivatives as potent (partial) agonists for human histamine H3 receptor. Bioorg Med Chem. 2010 Jul 15;18(14):5441-8.
7	Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first pote... J Pharmacol Exp Ther. 2005 Sep;314(3):1310-21.
8	Comparison of human, mouse, rat, and guinea pig histamine H4 receptors reveals substantial pharmacological species variation. J Pharmacol Exp Ther. 2001 Oct;299(1):121-30.
9	Histamine excites neonatal rat sympathetic preganglionic neurons in vitro via activation of H1 receptors. J Neurophysiol. 2006 Apr;95(4):2492-500.
10	Discovery of novel human histamine H4 receptor ligands by large-scale structure-based virtual screening. J Med Chem. 2008 Jun 12;51(11):3145-53.
11	Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol. 2001 Mar;59(3):420-6.