General Information of Drug (ID: DMYD4PC)

Drug Name
N-(4-Phenyl-pyridin-2-yl)-guanidine Drug Info
Synonyms CHEMBL54467; N-(4-Phenyl-pyridin-2-yl)-guanidine; Guanidine, N-(4-phenyl-2-pyridinyl)-; 2-(4-Phenyl-2-pyridinyl)guanidine; BDBM50108355
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
10219978
TTD Drug ID
DMYD4PC

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aminocaproic Acid DMFGND4 Bleeding disorder GA20-GA21 Approved [2]
2-(2-Hydroxy-phenyl)-1H-indole-5-carboxamidine DM3UMYD Discovery agent N.A. Investigative [3]
1-guanidino-N-phenyl-7-isoquinolinesulphonamide DMTF1HL Discovery agent N.A. Investigative [4]
BMS-344577 DM9WRUG Discovery agent N.A. Investigative [5]
N-(4-Chloro-7-p-tolyl-isoquinolin-1-yl)-guanidine DMNO46U Discovery agent N.A. Investigative [6]
5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACID DMPFX0S Discovery agent N.A. Investigative [7]
N-(7-Benzyloxy-isoquinolin-1-yl)-guanidine DMPMBC2 Discovery agent N.A. Investigative [6]
N-(5-Benzyloxy-isoquinolin-1-yl)-guanidine DMGAITY Discovery agent N.A. Investigative [6]
⏷ Show the Full List of 8 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tissue-type plasminogen activator (PLAT) TTXAGYU TPA_HUMAN Inhibitor [1]

References

1 Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 1: 2-Pyridinylguanidines. Bioorg Med Chem Lett. 2002 Jan 21;12(2):181-4.
2 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
3 Development of serine protease inhibitors displaying a multicentered short (<2.3 A) hydrogen bond binding mode: inhibitors of urokinase-type plasmi... J Med Chem. 2001 Aug 16;44(17):2753-71.
4 Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines. J Med Chem. 2007 May 17;50(10):2341-51.
5 Aroylguanidine-based factor Xa inhibitors: the discovery of BMS-344577. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6882-9.
6 Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 3: 1-isoquinolinylguanidines. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3227-30.
7 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.