Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYDG27)

• Drug Name: (R/S) EF-1500 Drug Info
• Synonyms: (R/S) EF-1500; GTPL4583

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 53319290
  TTD Drug ID: DMYDG27
  VARIDT Drug ID: DR01086

Molecule-Related Drug Atlas

Drug(s) Targeting Na(+)/Cl(-) betaine/GABA transporter (SLC6A12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LU32-176B	DM2YOVC	Discovery agent	N.A.	Investigative	[4]
(R)-EF-1520	DM297MU	Discovery agent	N.A.	Investigative	[3]
(S)-EF-1520	DM0EQTM	Discovery agent	N.A.	Investigative	[3]
NNC052090	DMCGF3U	Discovery agent	N.A.	Investigative	[5]

Drug(s) Targeting GABA transporter GAT-1 (SLC6A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tiagabine	DMKSQG0	Epilepsy	8A60-8A68	Approved	[2]
Metadoxine	DMM4QOJ	Multiple myeloma	2A83	Approved	[6]
GSK683699	DMTW79H	Inflammatory bowel disease	DD72	Phase 2	[7]
CI-966	DM8T2KA	Convulsion	8A68.Z	Phase 1	[8]
NIPECOTIC ACID	DMPV450	Discovery agent	N.A.	Investigative	[9]
2,4-Diamino-butyric acid(GABA)	DMAOGBP	Discovery agent	N.A.	Investigative	[10]
LU32-176B	DM2YOVC	Discovery agent	N.A.	Investigative	[4]
(R)-nipecotic acid	DMWGB40	Discovery agent	N.A.	Investigative	[7]
4-Hydroxy-piperidine-3-carboxylic acid	DM9VQ0T	Discovery agent	N.A.	Investigative	[11]
(R)-EF-1520	DM297MU	Discovery agent	N.A.	Investigative	[2]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
GABA transporter GAT-1 (SLC6A1)	TTPRKM0	SC6A1_HUMAN	Inhibitor	[2]
Na(+)/Cl(-) betaine/GABA transporter (SLC6A12)	TTQBMPI	S6A12_HUMAN	Inhibitor	[3]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4583).
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 929).
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 932).
• [4] First demonstration of a functional role for central nervous system betaine/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anti... J Pharmacol Exp Ther. 2005 Feb;312(2):866-74.
• [5] 1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methoxyphenyl)-4-piperidinol, a novel subtype selective inhibitor of the mouse type II GABA-transporter. Br J Pharmacol. 1997 Mar;120(6):983-5.
• [6] Company report (Alcobra pharma)
• [7] Novel secoergoline derivatives inhibit both GABA and glutamate uptake in rat brain homogenates: synthesis, in vitro pharmacology, and modeling. J Med Chem. 2004 Nov 4;47(23):5620-9.
• [8] Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur J Pharmacol. 1994 Oct 14;269(2):219-24.
• [9] Epimeric cis-decahydroquinoline-5-carboxylic acids: effects on gamma-aminobutyric acid uptake and receptor binding in vitro. J Med Chem. 1981 Jul;24(7):788-94.
• [10] Glycine antagonists. Synthesis, structure, and biological effects of some bicyclic 5-isoxazolol zwitterions. J Med Chem. 1986 Feb;29(2):224-9.
• [11] Hydroxy- and amino-substituted piperidinecarboxylic acids as gamma-aminobutyric acid agonists and uptake inhibitors. J Med Chem. 1982 Oct;25(10):1157-62.