Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYEMWB)

Drug Name

PMID22533316C1 Drug Info

Synonyms

GTPL6709

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Lanosterol synthase (LSS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ZD-9720	DMFV47R	Arteriosclerosis	BD40	Terminated	[2]
BIBB-515	DM6QT9P	Arteriosclerosis	BD40	Terminated	[3]
BIBX-79	DMRXWCO	Arteriosclerosis	BD40	Terminated	[4]
B-Octylglucoside	DMMO75G	Discovery agent	N.A.	Investigative	[5]
Lanosterol	DMHN74V	Discovery agent	N.A.	Investigative	[5]
PMID22533316C4	DMW3UHO	Discovery agent	N.A.	Investigative	[1]
PMID9003518C4	DMYE64O	Discovery agent	N.A.	Investigative	[6]
29-methylidene-2,3-oxidosqualene	DMUQAP7	Discovery agent	N.A.	Investigative	[6]
Tetradecane	DMK8P61	Discovery agent	N.A.	Investigative	[5]
PMID9003518C3	DM1I578	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	Cytotoxic effects of combination of oxidosqualene cyclase inhibitors with atorvastatin in human cancer cells. J Med Chem. 2012 Jun 14;55(11):4990-5002.
2	Toxicologic lesions associated with two related inhibitors of oxidosqualene cyclase in the dog and mouse. Toxicol Pathol. 2001 Mar-Apr;29(2):174-9.
3	Effects of a novel 2,3-oxidosqualene cyclase inhibitor on cholesterol biosynthesis and lipid metabolism in vivo. J Lipid Res. 1997 Mar;38(3):564-75.
4	Effects of a novel 2,3-oxidosqualene cyclase inhibitor on the regulation of cholesterol biosynthesis in HepG2 cells. J Lipid Res. 1996 Jan;37(1):148-58.
5	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
6	Synthesis and inhibition studies of sulfur-substituted squalene oxide analogues as mechanism-based inhibitors of 2,3-oxidosqualene-lanosterol cyclase. J Med Chem. 1997 Jan 17;40(2):201-9.