Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYQHER)

Drug Name
Diterpene triepoxide derivative 1 Drug Info
Synonyms PMID27977313-Compound-37
Cross-matching ID
PubChem CID
133613148
CAS Number
CAS 38748-32-2
TTD Drug ID
DMYQHER

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Thioredoxin reductase (PRDX5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [2]
Eptacog beta DMTY96S Chronic lymphocytic leukaemia 2A82.0 Phase 1/2 [3]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Thioredoxin reductase (PRDX5) TTLPJWH PRDX5_HUMAN Not Available [1]

References

1 Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556.
2 Mechanism of inhibition of ribonucleotide reductase with motexafin gadolinium (MGd). Biochem Biophys Res Commun. 2009 Feb 13;379(3):775-9.
3 APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase. Cell Death Dis. 2013 Oct 24;4:e881.