Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYSMWI)

Drug Name
K-454 Drug Info
Synonyms JAK2 kinase inhibitor (cancer), Kyowa
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Investigative [1]
Cross-matching ID
TTD Drug ID
DMYSMWI

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Janus kinase 2 (JAK-2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Momelotinib DMF98Q0 Myelofibrosis 2A20.2 Approved [2]
Baricitinib DM4ONW5 Rheumatoid arthritis FA20 Approved [3]
Ruxolitinib DM7Q98D Essential thrombocythemia 3B63.1Z Approved [4]
Pacritinib DM1T6ZN Myelofibrosis 2A20.2 Approved [5]
Fedratinib DM4ZBK6 Myelofibrosis 2A20.2 Approved [6]
ITF2357 DMFZBNE Duchenne dystrophy 8C70 Phase 3 [7]
XL019 DMJ6F5C Solid tumour/cancer 2A00-2F9Z Phase 3 [7]
Cerdulatinib DMSCR2H B-cell lymphoma 2A86 Phase 2 [8]
CTP-543 DM3SYOK Alopecia ED70 Phase 2 [9]
INCB039110 DMD9RV3 Malignant neoplasm 2A00-2F9Z Phase 2 [1]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Janus kinase 2 (JAK-2) TTRMX3V JAK2_HUMAN Inhibitor [1]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2048).
2 Genetic determinants of response and survival in momelotinib-treated patients with myelofibrosis.Leukemia.2015 Mar;29(3):741-4.
3 Selective JAK inhibitors in development for rheumatoid arthritis. Expert Opin Investig Drugs. 2014 Aug;23(8):1067-77.
4 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
5 National Cancer Institute Drug Dictionary (drug id 609888).
6 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
7 Emerging drugs for the therapy of primary and post essential thrombocythemia, post polycythemia vera myelofibrosis. Expert Opin Emerg Drugs. 2009 Sep;14(3):471-9.
8 Company report (Portola Pharmaceuticals)
9 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)