Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYTIP4)

Drug Name

Aleplasinin Drug Info

Synonyms

PAZ-417; PAI inhibitors (Alzheimers disease), Wyeth; Plasminogen activator inhibitor inhibitors (Alzheimers disease),Wyeth

Indication

Disease Entry	ICD 11	Status	REF
Alzheimer disease	8A20	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

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Drug(s) Targeting Plasminogen activator inhibitor (PAI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
XR-1853	DMFHR2O	Thrombosis	DB61-GB90	Terminated	[3]
T-686	DMOGQ2L	Arteriosclerosis	BD40	Terminated	[4]
XR-5082	DMEVSZO	Thrombosis	DB61-GB90	Terminated	[5]
BX-044	DM0P8CE	Thrombosis	DB61-GB90	Terminated	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Plasminogen activator inhibitor (PAI)	TT5QA2I	PAI1_HUMAN; PAI2_HUMAN; IPSP_HUMAN	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT00739037) Study Evaluating PAZ-417 in Cerebrospinal Fluid in Subjects With Alzheimer's Disease. U.S. National Institutes of Health.
2	CN patent application no. 102046168, Pai-1 expression and activity inhibitors for the treatment of ocular disorders.
3	Characterization and comparative evaluation of a novel PAI-1 inhibitor. Thromb Haemost. 2002 Jul;88(1):137-43.
4	T-686, a novel inhibitor of plasminogen activator inhibitor-1, inhibits thrombosis without impairment of hemostasis in rats. Eur J Pharmacol. 1997 Jul 9;330(2-3):151-6.
5	Evaluation of a low molecular weight modulator of human plasminogen activator inhibitor-1 activity. Thromb Haemost. 1996 May;75(5):808-15.
6	Characterization of a small molecule PAI-1 inhibitor, ZK4044. Thromb Res. 2005;115(4):341-50.