Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYWM56)

Drug Name

GNE-7915 Drug Info

Synonyms

GNE7915; GNE 7915

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting Leucine-rich repeat kinase 2 (LRRK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DNL151	DMZT89C	Parkinson disease	8A00.0	Phase 1	[3]
DNL201	DMFEORD	Parkinson disease	8A00.0	Phase 1	[3]
BIIB094	DMLUO5K	Parkinson disease	8A00.0	Phase 1	[4]
Pyrrolo-pyridine derivative 2	DMVNY5I	N. A.	N. A.	Patented	[5]
Bidentate ligands of Markush derivative 2	DM2QNMC	N. A.	N. A.	Patented	[5]
Oxindole derivative 3	DM0ENF3	N. A.	N. A.	Patented	[5]
Aminopyridine derivative 3	DMSLJE8	N. A.	N. A.	Patented	[5]
Fused thiophene derivative 1	DMV7IX4	N. A.	N. A.	Patented	[5]
Oxindole derivative 4	DM3U58I	N. A.	N. A.	Patented	[5]
Bidentate ligands of Markush derivative 1	DMB08D3	N. A.	N. A.	Patented	[5]
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Drug(s) Targeting Dual specificity protein kinase TTK (MPS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BOS172722	DMU790L	Solid tumour/cancer	2A00-2F9Z	Phase 1	[6]
BAY1161909	DMUK6YM	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]
CFI-402257	DMH701Q	Solid tumour/cancer	2A00-2F9Z	Phase 1	[8]
Tricyclic isoxazoloquinazoline derivative 2	DMH4TY1	N. A.	N. A.	Patented	[9]
Tricyclic isoxazoloquinazoline derivative 4	DM8VIM4	N. A.	N. A.	Patented	[9]
Tricyclic isoxazoloquinazoline derivative 3	DML2PWF	N. A.	N. A.	Patented	[9]
2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One	DMDN12L	Discovery agent	N.A.	Investigative	[10]
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⏷ Show the Full List of 7 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dual specificity protein kinase TTK (MPS1)	TTP7EGM	TTK_HUMAN	Inhibitor	[2]
Leucine-rich repeat kinase 2 (LRRK2)	TTK0FEA	LRRK2_HUMAN	Inhibitor	[2]

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References

1	Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. J Med Chem. 2012 Nov 26;55(22):9416-33.
2	Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. J Med Chem. 2014 Feb 13;57(3):921-36.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Clinical pipeline report, company report or official report of Ionis
5	Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676.
6	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
7	National Cancer Institute Drug Dictionary (drug id 761238).
8	Functional characterization of CFI-402257, a potent and selective Mps1/TTK kinase inhibitor, for the treatment of cancer. Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3127-3132.
9	Protein kinase R(PKR)-like endoplasmic reticulum kinase (PERK) inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Jan;27(1):37-48.
10	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.