General Information of Drug (ID: DMYZE8R)

Drug Name
ISIS 7948 Drug Info
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
TTD Drug ID
DMYZE8R

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Discontinued Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BALANOL DMDLN9E N. A. N. A. Terminated [2]
RO-316233 DMAGLPW Discovery agent N.A. Investigative [3]
Bisindolylmaleimide-I DMOQJZC Discovery agent N.A. Investigative [4]
PROSTRATIN DM1HMJ5 Human immunodeficiency virus infection 1C62 Investigative [5]
8-Octyl-benzolactam-V9 DM4Z15M Discovery agent N.A. Investigative [6]
chelerythrine DMCP1G9 Discovery agent N.A. Investigative [7]
ISIS 7942 DMN0A1R Discovery agent N.A. Investigative [1]
⏷ Show the Full List of 7 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
PKC-epsilon messenger RNA (PRKCE mRNA) TT57MT2 KPCE_HUMAN Not Available [1]

References

1 US patent application no. 5,959,096, Antisense oligonucleotides against human protein kinase C.
2 Evaluation of differential hypoxic cytotoxicity and electrochemical studies of nitro 5-deazaflavins, Bioorg. Med. Chem. Lett. 5(18):2155-2160 (1995).
3 Synthesis of anilino-monoindolylmaleimides as potent and selective PKCbeta inhibitors. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5171-4.
4 Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2... J Biol Chem. 2007 Nov 9;282(45):33052-63.
5 A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. J Med Chem. 1992 May 29;35(11):1978-86.
6 Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta. J Med Chem. 2006 May 4;49(9):2681-8.
7 A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8.