Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYZQKC)

Drug Name

SPHINX31 Drug Info

Synonyms

1818389-84-2; N-(2-(4-(pyridin-2-ylmethyl)piperazin-1-yl)-5-(trifluoromethyl)phenyl)-5-(pyridin-4-yl)furan-2-carboxamide; 5-(4-pyridinyl)-N-[2-[4-(2-pyridinylmethyl)-1-piperazinyl]-5-(trifluoromethyl)phenyl]-2-furancarboxamide; SPHINX 31;SPHINX-31; SCHEMBL17196904; BDBM221074; AMY11306; BCP30381; EX-A2804; s8810; BS-16147; HY-117661; CS-0066777; US9695160, 12; RXZ

Indication

Disease Entry	ICD 11	Status	REF
Wet age-related macular degeneration	9B78.3Z	Preclinical	[1]

Cross-matching ID

PubChem CID: 91972002
TTD Drug ID: DMYZQKC

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting SRSF protein kinase 1 (SRPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ZINC959121	DMR0F4H	N. A.	N. A.	Patented	[2]
Sphinx	DMJF6S0	N. A.	N. A.	Patented	[2]
SPHINX scaffold, 3	DM8XJTH	N. A.	N. A.	Patented	[2]
PMID15925511C13	DMHY95J	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
SRSF protein kinase 1 (SRPK1)	TTU3WV6	SRPK1_HUMAN	Inhibitor	[1]

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References

1	Kinase inhibitors: the road ahead. Nat Rev Drug Discov. 2018 May;17(5):353-377.
2	Piperazine derivatives for treating disorders. US9695160.
3	Synthesis of selective SRPK-1 inhibitors: novel tricyclic quinoxaline derivatives. Bioorg Med Chem Lett. 2005 Jul 1;15(13):3241-6.