General Information of Drug (ID: DMZ26LS)

Drug Name
6-fluoromevalonate pyrophosphate Drug Info
Synonyms 6-FMevPP
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
44306087
TTD Drug ID
DMZ26LS

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID17888661C18 DMLPC17 Discovery agent N.A. Investigative [3]
P'-geranyl 3,5,8-trihydroxy-3-methyloctanate 8-diphosphate DMO9BUR Discovery agent N.A. Investigative [4]
P'-geranyl 3,5,9-trihydroxy-3-methylnonanate 9-diphosphate DM2395E Discovery agent N.A. Investigative [4]
P'-geranyl 3,5,7-trihydroxy-3-methylheptanate 7-diphosphate DMJ4SIA Discovery agent N.A. Investigative [4]
diphosphoglycolyl proline DM28NIU Discovery agent N.A. Investigative [5]
PMID17888661C19 DMRWTHA Discovery agent N.A. Investigative [3]
analog 3 (Vlattas et al., 1996) DMMKGT4 Discovery agent N.A. Investigative [2]
2,2-difluoromevalonate 5-diphosphate DMKXFDA Discovery agent N.A. Investigative [3]
P'-geranyl 2-fluoromevalonate 5-diphosphate DMNY187 Discovery agent N.A. Investigative [5]
2-fluoromevalonate 5-diphosphate DMEQRHY Discovery agent N.A. Investigative [6]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Diphosphomevalonate decarboxylase (MVD) TTE5J6X MVD1_HUMAN Inhibitor [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7996).
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 642).
3 Mutation and inhibition studies of mevalonate 5-diphosphate decarboxylase. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6164-8.
4 Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase. Org Lett. 2006 Mar 16;8(6):1013-6.
5 Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure. Arch Biochem Biophys. 2008 Dec 1;480(1):58-67.
6 Inhibition of mevalonate 5-diphosphate decarboxylase by fluorinated substrate analogs. Biochim Biophys Acta. 2006 Jul;1760(7):1080-7.