Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZ5NQP)

• Drug Name: A-11259 Drug Info
• Synonyms: A-00000762; A-00000764; A-00026158; A-00026161; A-764; Shikimate kinase inhibitors (antibacterial); Shikimate kinase inhibitors (antibacterial), Arrow

Indication

Disease Entry	ICD 11	Status	REF
Bacterial infection	1A00-1C4Z	Terminated	[1]

• Cross-matching ID: TTD Drug ID: DMZ5NQP

Molecule-Related Drug Atlas

Drug(s) Targeting Enzyme unspecific (Enz)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[3]
Desoxyribonuclease	DMEZFXR	Female genital tract inflammation	GA0Z	Approved	[4]
VT-1129	DMCGK9H	Onchocerciasis	1F6A	Phase 2	[5]
HTI-101	DMURXMJ	Obesity	5B81	Phase 2	[6]
ASC-101	DMVNCSK	Haematological malignancy	2B33.Y	Phase 1/2	[7]
BXCL702	DMY9L4C	Haematological malignancy	2B33.Y	Phase 1	[8]
NZ-1002	DMINSRW	Lysosomal storage disease	5C56.Z	Terminated	[9]
SRI-3072	DMBEUN6	Mycobacterium infection	1B10-1B21	Terminated	[10]
GW-278884	DMUG82P	Colorectal cancer	2B91.Z	Terminated	[11]
BM-13677	DMKITQN	Diabetic complication	5A2Y	Terminated	[12]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Enzyme unspecific (Enz)	TT3C1VN	NOUNIPROTAC	Inhibitor	[2]

References

• [1] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016810)
• [2] The Identification of Nanomolar 1,4-benzoquinone Inhibitors of Shikimate Kinase. Aspergillus & Aspergillosis Website. 2002.
• [3] Methionine and cysteine affect glutathione level, glutathione-related enzyme activities and the expression of glutathione S-transferase isozymes in rat hepatocytes. J Nutr. 1997 Nov;127(11):2135-41.
• [4] Preparation of the bifunctional enzyme ribonuclease-deoxyribonuclease by cross-linkage. Biochemistry. 1979 Oct 2;18(20):4449-52.
• [5] The clinical candidate VT-1161 is a highly potent inhibitor of Candida albicans CYP51 but fails to bind the human enzyme. Antimicrob Agents Chemother. 2014 Dec;58(12):7121-7.
• [6] Halozyme Therapeutics Announces New Studies From HTI-101 Presented at Proteoglycan Research Conference. Halozyme Therapeutics. JULY 12, 2006.
• [7] ClinicalTrials.gov (NCT01983761) Study of ASC-101 in Patients With Hematologic Malignancies Who Receive Dual-cord Umbilical Cord Blood Transplantation. U.S. National Institutes of Health.
• [8] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [9] Expression of a cytokinin synthesis gene from Agrobacterium tumefaciens T-DNA in basket willow (Salix viminalis). Physiologia Plantarum Volume 88, Issue 3, pages 439-445, July 1993.
• [10] 2-Alkoxycarbonylaminopyridines: inhibitors of Mycobacterium tuberculosis FtsZ. J Antimicrob Chemother. 2002 Jul;50(1):111-4.
• [11] WO patent application no. 2010,1112,71, Orally bioavailable lipid-based constructs.
• [12] Progress in medicinal chemistry, 1994. Page(448).