Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZ76NQ)

Drug Name

6-Phenylsulfanyl-9H-purine Drug Info

Synonyms

Purine, 6-(phenylthio)-; 6-(Phenylthio)purine; 1H-Purine, 6-(phenylthio)-; 5450-35-1; NSC 15746; UNII-3KH11DU8DY; 6-phenylsulfanyl-7H-purine; BRN 0013668; 3KH11DU8DY; AI3-52068; AC1Q4XUH; AC1L3TI0; 4-26-00-01985 (Beilstein Handbook Reference); 9H-Purine,6-(phenylthio)-; SCHEMBL796397; 6-(phenylsulfanyl)-7H-purine; CHEMBL175600; 9H-Purine, 6-(phenylthio)-; CTK5A1336; DTXSID20202908; NSC15746; ZINC13608565; NSC-15746; AKOS030562402

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 95065
CAS Number: CAS 5450-35-1
TTD Drug ID: DMZ76NQ

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Stress-activated protein kinase 2a (p38 alpha)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ozagrel	DMIGKA1	Xerophthalmia	5B55.Y	Phase 4	[2]
Losmapimod	DMIL37Z	Acute coronary syndrome	BA41	Phase 3	[2]
VX-702	DMKJDR6	Coronary artery disease	BA80	Phase 2a	[3]
VX-745	DMJAEG6	Alzheimer disease	8A20	Phase 2	[4]
Dilmapimod	DMBYJ92	Acute lung injury	NB32.3	Phase 2	[2]
PMID25991433-Compound-A1	DM89LF0	N. A.	N. A.	Patented	[5]
PMID25991433-Compound-F2	DM37VIQ	N. A.	N. A.	Patented	[5]
PMID25991433-Compound-L2	DM58UO9	N. A.	N. A.	Patented	[5]
PMID25991433-Compound-L3	DM3LWUR	N. A.	N. A.	Patented	[5]
PMID25991433-Compound-L1	DM2135Y	N. A.	N. A.	Patented	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Stress-activated protein kinase 2a (p38 alpha)	TTQBR95	MK14_HUMAN	Inhibitor	[1]

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References

1	Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors. J Med Chem. 2005 Feb 10;48(3):710-22.
2	Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
3	Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies. Arthritis Rheum. 2009 May;60(5):1232-41.
4	Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci. 2002 Jan;23(1):40-5.
5	c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72.