Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZ8PY0)

Drug Name

ACE-031 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Duchenne dystrophy	8C70	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Growth/differentiation factor 8 (GDF-8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LY2495655	DMM5JAN	Disuse muscle atrophy	8B61	Phase 2	[3]
AMG 745	DMFXN2T	Muscle atrophy	FB32.Y	Phase 2	[4]
PF-06252616	DMQLZOF	Duchenne dystrophy	8C70	Phase 2	[3]
SAR391786	DMS1YPZ	Muscle atrophy	FB32.Y	Phase 2	[5]
Domagrozumab	DMCT08V	Duchenne dystrophy	8C70	Phase 2	[6]
Stamulumab	DMBCIXL	Duchenne dystrophy	8C70	Phase 1/2	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Growth/differentiation factor 8 (GDF-8)	TTSWPH8	GDF8_HUMAN	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT01099761) Study of ACE-031 in Subjects With Duchenne Muscular Dystrophy. U.S. National Institutes of Health.
2	A single ascending-dose study of muscle regulator ACE-031 in healthy volunteers. Muscle Nerve. 2013 Mar;47(3):416-23.
3	Myostatin inhibitors as therapies for muscle wasting associated with cancer and other disorders. Curr Opin Support Palliat Care. 2013 November; 7(4): 352-360.
4	The role of myostatin in muscle wasting: an overview. J Cachexia Sarcopenia Muscle. 2011 September; 2(3): 143-151.
5	Myostatin (GDF-8) as a key factor linking muscle mass and bone structure. J Musculoskelet Neuronal Interact. 2010 Mar;10(1):56-63.
6	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)