Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZCG91)

• Drug Name: CSL-112 Drug Info
• Synonyms: Reconstituted HDL (acute coronary syndrome), CSL

Indication

Disease Entry	ICD 11	Status	REF
Arteriosclerosis	BD40	Phase 2	[1]
Cardiovascular disease	BA00-BE2Z	Phase 2	[2]

• Cross-matching ID: TTD Drug ID: DMZCG91

Molecule-Related Drug Atlas

Drug(s) Targeting Apolipoprotein A-I (APOA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CER-001	DMWUQI9	Acute coronary syndrome	BA41	Phase 2	[4]
CER-522	DMGAW0H	Aortic valve stenosis	BB70	Phase 1	[5]
MDCO-216	DMAQ24G	Arteriosclerosis	BD40	Phase 1	[6]
CRD-5	DMVU4A5	Hyperlipidaemia	5C80	Discontinued in Phase 2	[7]
APP-018	DM5L9I2	Arteriosclerosis	BD40	Discontinued in Phase 1	[8]
AMT-050	DMMKOCL	Cholesterol metabolism disorder	5C8Z	Terminated	[9]
LSI-518P	DMFJPYV	Cardiovascular disease	BA00-BE2Z	Terminated	[10]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Apolipoprotein A-I (APOA1)	TT7GN3U	APOA1_HUMAN	Modulator	[3]

References

• [1] ClinicalTrials.gov (NCT02108262) A Phase 2b Study of CSL112 in Subjects With Acute Myocardial Infarction.. U.S. National Institutes of Health.
• [2] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [3] CER-001, a HDL-mimetic, stimulates the reverse lipid transport and atherosclerosis regression in high cholesterol diet-fed LDL-receptor deficient mice. Atherosclerosis. 2014 Jan;232(1):110-8.
• [4] Clinical pipeline report, company report or official report of Cerenis.
• [5] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033541)
• [6] MDCO-216 (Apo A-I Milano/POPC Complex) Administered to Cynomolgus Monkeys Induces Pronounced Changes in Plasma Lipids and Apolipoproteins. Circulation. 2011; 124: A10978.
• [7] Emerging antidyslipidemic drugs. Expert Opin Emerg Drugs. 2008 Jun;13(2):363-81.
• [8] Apolipoprotein A-I and its mimetics for the treatment of atherosclerosis. Curr Opin Investig Drugs. 2010 September; 11(9): 989-996.
• [9] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026835)
• [10] Clinical review: The evolving role of HDL in the treatment of high-risk patients with cardiovascular disease. J Clin Endocrinol Metab. 2011 May;96(5):1246-57.