Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZENGX)

Drug Name

PMID24793884C77 Drug Info

Synonyms

GTPL8217; BDBM50016166

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting CDC7-related kinase (CDC7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BMS-863233	DM5HUY8	Haematological malignancy	2B33.Y	Phase 1/2	[2]
TAK-931	DM1ALY9	Solid tumour/cancer	2A00-2F9Z	Phase 1	[3]
PMID26161698-Compound-44	DM8UPO3	N. A.	N. A.	Patented	[4]
PMID19115845C89S	DMB9F2L	Discovery agent	N.A.	Investigative	[5]
PMID20873740C18	DMVHR3Z	Discovery agent	N.A.	Investigative	[6]
PMID24793884C74	DMFSJQC	Discovery agent	N.A.	Investigative	[1]
PHA-767491	DM4H7D5	Discovery agent	N.A.	Investigative	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	Synthesis and structure-activity relationship of trisubstituted thiazoles as Cdc7 kinase inhibitors. Eur J Med Chem. 2014 Jun 10;80:364-82.
2	Discovery of XL413, a potent and selective CDC7 inhibitor. Bioorg Med Chem Lett. 2012 Jun 1;22(11):3727-31.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70.
5	First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery. J Med Chem. 2009 Jan 22;52(2):293-307.
6	Cdc7 kinase inhibitors: 5-heteroaryl-3-carboxamido-2-aryl pyrroles as potential antitumor agents. 1. Lead finding. J Med Chem. 2010 Oct 28;53(20):7296-315.
7	Drug design with Cdc7 kinase: a potential novel cancer therapy target. Drug Des Devel Ther. 2009 Feb 6;2:255-64.