General Information of Drug (ID: DMZIA1R)

Drug Name
mercaptoacrylate inhibitor of calpain 1 Drug Info
Synonyms mercaptoacrylate inhibitor of calpain 1; GTPL8570; CHEMBL3221938; (Z)-3-(5-bromo-1H-indol-3-yl)-2-sulfanylprop-2-enoic acid
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
90668184
TTD Drug ID
DMZIA1R

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Drug(s) Targeting Calpain-2 (CAPN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ABT-957 DMB9N4J Alzheimer disease 8A20 Phase 1 [3]
PMID25399719-Compound-17 DMRXKJZ N. A. N. A. Patented [4]
Epoxysuccinate derivative 9 DM49FU0 N. A. N. A. Patented [4]
Epoxysuccinate derivative 4 DMCF6M8 N. A. N. A. Patented [4]
Carboxamide derivative 7 DM8TQS4 N. A. N. A. Patented [4]
Epoxysuccinate derivative 7 DMTSPVF N. A. N. A. Patented [4]
Carboxamide derivative 10 DM5WMO9 N. A. N. A. Patented [4]
Carboxamide derivative 11 DM1DN94 N. A. N. A. Patented [4]
Carboxamide derivative 8 DM6HI34 N. A. N. A. Patented [4]
Epoxysuccinate derivative 10 DMYF39U N. A. N. A. Patented [4]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Calpain-2 (CAPN2) TTG5QB7 CAN2_HUMAN Inhibitor [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8570).
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2336).
3 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
4 An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31.