Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZJUV6)

• Drug Name: CSJ117 Drug Info
• Synonyms: Ecleralimab

Indication

Disease Entry	ICD 11	Status	REF
Asthma	CA23	Phase 2	[1]
Chronic obstructive pulmonary disease	CA22	Phase 2	[2]

• Cross-matching ID: TTD Drug ID: DMZJUV6

Molecule-Related Drug Atlas

Drug(s) Targeting Thymic stromal lymphopoietin (TSLP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tezepelumab	DM9R5J6	Severe asthma	CA23	Approved	[4]
A378	DMUWRTB	Asthma	CA23	IND submitted	[5]
MEDI9929	DMGD1YP	Asthma	CA23	Phase 2	[6]
AMG 104	DM3XC31	Asthma	CA23	Phase 1	[7]
AZD8630	DMMUF0O	Asthma	CA23	Phase 1	[8]
PF-07275315	DMHRVUY	Atopic dermatitis	EA80	Phase 1	[9]
SAR443765	DMLYI4Z	Asthma	CA23	Phase 1	[10]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Thymic stromal lymphopoietin (TSLP)	TTHMW3T	TSLP_HUMAN	Inhibitor	[3]

References

• [1] ClinicalTrials.gov (NCT04410523) A 12-week, Multicenter, Randomized, Double-blind, Parallel-arm, Placebo-controlled Study to Assess the Efficacy and Safety of CSJ117, When Added to Existing Asthma Therapy in Patients >= 18 Years of Age With Severe Uncontrolled Asthma. U.S.National Institutes of Health.
• [2] ClinicalTrials.gov (NCT04882124) A 12-week Randomized, participant-and Investigator-blinded, Placebo-controlled, Parallel Group Study to Explore the Efficacy, Pharmacodynamics, Safety, and Pharmacokinetics of Two Doses of Inhaled CSJ117 in Adults With Chronic Obstructive Pulmonary Disease (COPD). U.S.National Institutes of Health.
• [3] TSLP Inhibitors for Asthma: Current Status and Future Prospects. Drugs. 2020 Apr;80(5):449-458.
• [4] Tezepelumab in Adults with Uncontrolled Asthma. N Engl J Med. 2017 Sep 7;377(10):936-946.
• [5] Clinical pipeline report, company report or official report of Klus Pharma
• [6] Human immunoglobulin G2Lambda monoclonal antibody directed against thymic stromal lymphopoietin (MEDI9929). European medicines agency science medicines health (EMEA-001613-PIP01-14). European Union. 2015.
• [7] Clinical pipeline report, company report or official report of Amgen
• [8] Clinical pipeline report, company report or official report of AstraZeneca
• [9] Clinical pipeline report, company report or official report of Pfizer
• [10] Clinical pipeline report, company report or official report of Sanofi