Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZT89C)

Drug Name

DNL151 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Parkinson disease	8A00.0	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Leucine-rich repeat kinase 2 (LRRK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DNL201	DMFEORD	Parkinson disease	8A00.0	Phase 1	[1]
BIIB094	DMLUO5K	Parkinson disease	8A00.0	Phase 1	[2]
Pyrrolo-pyridine derivative 2	DMVNY5I	N. A.	N. A.	Patented	[3]
Bidentate ligands of Markush derivative 2	DM2QNMC	N. A.	N. A.	Patented	[3]
Oxindole derivative 3	DM0ENF3	N. A.	N. A.	Patented	[3]
Aminopyridine derivative 3	DMSLJE8	N. A.	N. A.	Patented	[3]
Fused thiophene derivative 1	DMV7IX4	N. A.	N. A.	Patented	[3]
Oxindole derivative 4	DM3U58I	N. A.	N. A.	Patented	[3]
Bidentate ligands of Markush derivative 1	DMB08D3	N. A.	N. A.	Patented	[3]
Pyrrolo-pyrimidine derivative 8	DMZH27I	N. A.	N. A.	Patented	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Leucine-rich repeat kinase 2 (LRRK2)	TTK0FEA	LRRK2_HUMAN	Inhibitor	[1]

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Clinical pipeline report, company report or official report of Ionis
3	Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676.