Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZVJYL)

Drug Name

PcTx1 Drug Info

Synonyms

CIGUATOXIN; Ciguatoxin 1; Ciguatoxin CTX 1; Pacific ciguatoxin 1; CTX 1; P-CTX 1; UNII-2UKQ3B7696; HSDB 7241; 11050-21-8; 2UKQ3B7696; Pacific ciguatoxin-1; P-CTX-1; Ciguatoxins; Ciguatoxin CTX1B; Ciguatoxin I; Ciguatoxin 1B; SCHEMBL13303026; DTXSID3042637; NOCAS_42637; CHEBI:36467; LS-53705; C16762

Indication

Disease Entry	ICD 11	Status	REF
Pain	MG30-MG3Z	Investigative	[1]

Therapeutic Class

Analgesics

Cross-matching ID

PubChem CID: 90489000
TTD Drug ID: DMZVJYL

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Acid-sensing ion channel 1 (ASIC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amiloride	DMRTSGP	Congestive heart failure	BD10	Approved	[3]
PPC-5650	DM2D7Z0	Pain	MG30-MG3Z	Phase 1	[4]
------------------------------------------------------------------------------------

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Acid-sensing ion channel 1 (ASIC1)	TTRJYB6	ASIC1_HUMAN	Blocker	[2]

------------------------------------------------------------------------------------

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4292).
2	Challenges in analgesic drug development. Clin Pharmacol Ther. 2009 Oct;86(4):447-50.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	ClinicalTrials.gov (NCT01449487) Investigation of Efficacy and Safety of PPC-5650 to Experimental Induced Sensation and Pain in the Rectosigmoid. U.S. National Institutes of Health.