General Information of Drug (ID: DMZWNQF)

Drug Name
2'3'-Dideoxyinosine Drug Info
Cross-matching ID
PubChem CID
16219192
TTD Drug ID
DMZWNQF

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BCX-3408 DMRSG31 Autoimmune diabetes 5A10 Phase 2 [2]
Forodesine DME2W4T B-cell acute lymphoblastic leukaemia 2B33.3 Phase 1/2 [3]
Guanosine DM4T5LH N. A. N. A. Phase 1 [1]
Peldesine DMHV58T N. A. N. A. Phase 1 [1]
CI-972 DM9ZBO0 Rheumatoid arthritis FA20 Discontinued in Phase 1 [4]
7-tert-butyl-2, 3-dihydro-3, 3-dimethyl substituted dihydrofuran 30 (DHDMBF30) DMSU06X Discovery agent N.A. Investigative [5]
Hypoxanthine DMLSABI Discovery agent N.A. Investigative [1]
8-Iodo-Guanine DM3K1EO Discovery agent N.A. Investigative [1]
8-Azaguanine DM7VP90 Discovery agent N.A. Investigative [1]
MT-Immucillin-H DMK2FOX Discovery agent N.A. Investigative [6]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Purine nucleoside phosphorylase (PNP) TTMCF1Y PNPH_HUMAN Inhibitor [1]

References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2 BCX-4208 (RO5092888), a Purine Nucleoside Phosphorylase (PNP) Inhibitor, Is a Novel, Potent Orally Active Anti-T-Cell and B-Cell Agent. 50th ASH Annual Meeting and Exposition. 2008.
3 Forodesine has high antitumor activity in chronic lymphocytic leukemia and activates p53-independent mitochondrial apoptosis by induction of p73 an... Blood. 2009 Aug 20;114(8):1563-75.
4 Inhibitors of human purine nucleoside phosphorylase. Synthesis of pyrrolo[3,2-d]pyrimidines, a new class of purine nucleoside phosphorylase inhibitors as potentially T-cell selective immunosuppressive agents. Description of 2,6-diamino-3,5-dihydro-7-(3-thienylmethyl)-4H-pyrrolo[3,2-d] pyrimidin-4-one. J Med Chem. 1992 May 1;35(9):1605-9.
5 Expression of human malaria parasite purine nucleoside phosphorylase in host enzyme-deficient erythrocyte culture. Enzyme characterization and identification of novel inhibitors. J Biol Chem. 1986 Sep 5;261(25):11667-73.
6 Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function. J Biol Chem. 2004 Apr 30;279(18):18103-6.