Details of the Drug Reposition | DrugMAP

General Information of This Drug (ID: DM5HO2X)

Drug Name	Ponsegromab DM5HO2X
Synonyms	PF-06946860
Drug Type	Monoclonal antibody

Information on Drug Reposition of This Drug

Molecular Interaction Atlas (MIA)

2 Phase 2 Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Heart failure	DISJW62S	BD10-BD13	Phase 2	[1]
Cancer cachexia	DIS6CAY2	MG20.0	Phase 2	[2]
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References

1	ClinicalTrials.gov (NCT05492500) A PHASE 2, DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, 4-ARM STUDY TO INVESTIGATE SYMPTOMS, FUNCTION, HEALTH-RELATED QUALITY OF LIFE AND SAFETY WITH REPEATED SUBCUTANEOUS ADMINISTRATION OF PONSEGROMAB VERSUS PLACEBO IN ADULT PARTICIPANTS WITH HEART FAILURE. U.S.National Institutes of Health.
2	ClinicalTrials.gov (NCT05546476) A PHASE 2, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO INVESTIGATE THE EFFICACY, SAFETY AND TOLERABILITY OF PONSEGROMAB IN PATIENTS WITH CANCER, CACHEXIA, AND ELEVATED CONCENTRATIONS OF GDF-15, FOLLOWED BY AN OPTIONAL OPEN-LABEL TREATMENT PERIOD (PROACC -1). U.S.National Institutes of Health.